Current technical strategies for management of female genital schistosomiasis (FGS) are not feasible within primary healthcare settings. This article presents an evaluation of piloting FGS care package in two local government areas (LGAs) of Ogun State, Nigeria. Results show that out of 79 women and girls screened, 66 were treated and followed up. Health workers assimilated knowledge of FGS and effectively diagnosed and managed patients, demonstrating the feasibility of using symptomatic screening and treatment tools to diagnose and care for women or girls with suspected FGS. Referral issues, gender norms that limited uptake and sensitisation, and limited capacity of the workforce are key challenges.