Conjunctival fibrosis and the innate barriers to Chlamydia trachomatis intracellular infection: a genome wide association study

Chlamydia trachomatis causes both trachoma and sexually transmitted infections. These diseases have similar pathology and potentially similar genetic predisposing factors.

This study aimed to identify polymorphisms and pathways associated with pathological sequelae of ocular Chlamydia trachomatis infections in The Gambia. Although unconfirmed, the data suggest that genetic associations with chlamydial scarring disease may be focused on processes relating to the immune response, the host cell cycle and cell surface receptor signalling.