Serological and PCR-based markers of ocular Chlamydia trachomatis transmission in northern Ghana after elimination of trachoma as a public health problem

Summary

Validation of elimination of trachoma as a public health problem is based on clinical indicators, which is increasingly problematic. Alternative indicators (antibody and infection) were integrated into the pre-validation trachoma surveys conducted in Ghana in 2015 and 2016.

This study shows that elimination of trachoma as a public health problem does not equate to the absence of ocular ‘Chlamydia trachomatis’ (Ct) infection, nor cessation in acquisition of anti-Ct antibodies. Infection and serological data provide useful information to aid in understanding Ct transmission dynamics and identify communities at potential risk of recrudescence.